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STEM CELL THERAPY IN REPRODUCTOLOGY

  • Thin and non-receptive endometrium
  • Premature ovarian failure
  • Amenorrhea
  • Hypergonadotropism
  • Hypoestrogenism
  • Early menopause
  • Prolongation of ovarian reserve
  • Polycystic ovary syndrome

Stem cell therapy using Mesenchymal Stem Cells is absolutely safe. There are no side effects associated with stem cell therapy. In very rare cases: a slight increase in temperature after the procedure is possible; slight redness at the injection site, – all these effects pass within a few hours.

But there is a list of contraindications due to health conditions of the patient:

  • Malignant neoplasms
  • Critical disorders of blood coagulation system (platelet count ≤50×109)
  • Severe heart failure
  • Severe pulmonary failure (SpO2 <90%)
  • Kidney failure of IV-V degree
  • Infectious diseases in the acute phase (hepatitis C, hepatitis B, etc.)
  • Unstable hemodynamics, requiring correction with sympathomimetics
  • Terminal stage of incurable diseases
  • Acute stage of injuries or stroke
  • Pregnancy, pregnancy planning in the near future, breast feeding
  • Purulent joint diseases

The therapeutic effect of stem cells is achieved due to their ability to differentiate and transdifferentiate into tissue-specific cells, to fuse with the resident cells, to secrete a wide array of paracrine factors in order to stimulate the survival and functional recovery of the resident cells or to regulate the local microenvironment or immune response.

Mesenchymal stem cell treatment improves hormone production, ovarian size, endometrial thickness, and endometrial blood flow.

Stem cell treatment restores ovarian function and leads to the production of immature oocytes. In women, ultrasounds demonstrated that mesenchymal stem cell treatment improved both ovarian size and endometrial thickness of patient with premature ovarian failure. Moreover, blood flow analysis demonstrated a richer signal in the endometrium. In a recent study stem cell treatment of premature ovarian failure resumed menstruations and allowed a woman to get pregnant and to give birth to a full-term healthy baby.

Our Treatment Programs in Reproductology

Breakthrough study demonstrates the ‘re-awakening’ of the ovaries and achieves pregnancy in woman with premature ovarian failure using stem cells.

The use of stem cells to “re-awaken” the ovaries in women with premature ovarian failure (POF) pave the way for novel treatments for this cause of infertility, says GlobalData, a leading data and analytics company. Despite their young age, POF patients face a difficult-to-treat infertility issue with limited treatment options and relatively poor fertility outcomes.

Women who received stem cell injections experienced increased oestrogen levels, symptoms from hot flashes and insomnia decreased, and after six months, their periods began again. What’s more, no complications or safety issues have been reported making it an extremely viable option for women going forward.

  • 20+ patient`s exams included
  • 2 doctor`s consultations
  • Up to 30 mln of stem cells
  • Medical follow up for 1 year
  • 24/7 support
  • Translation
  • Transfer

Medical examination before stem cell therapy Gynecology

Included*:

  • General blood test and leukocyte formula, 1 day
  • Vitamin D
  • D-dimer
  • Complex “Infectious monitoring of the patient” Complex “Infectious monitoring of the patient”
  • Rapid test for the diagnosis of multi-infection (HIV, hepatitis B HBSAg, hepatitis C, syphilis)
  • Coagulogram: prothrombin time (PP), prothrombin index (PTI), international normalized ratio (MNO, INR), percentage of prothrombin according to Quick, thrombin time (PM), activated partial thromboplastin (APTT), fibrinogen 1F
  • Complex “Lipidogram”: cholesterol, triglycerides, HDL, LDL, atherogenic factor, 1 day
  • General analysis of urine, 1 day
  • Urea, 1 day
  • Creatinine, 1 day
  • Bilirubin fractional (total, direct, indirect), 1 day
  • Glycated hemoglobin (HbA1c), 1 day
  • Alanine aminotransferase (ALT), 1 day
  • Aspartate aminotransferase (AST), 1 day
  • Alkaline phosphatase (LF), 1 day
  • Human chorionic gonadotropin (beta-HCG) total, 1 day
  • Oncomarker of ovarian cancer (CA-125), 2 days
  • Breast cancer tumor marker (CA-153), 2 days
  • Prostate-specific antigen total (Total PSA), 1 day
  • Initial consultation with a therapist

 

The list of examination can be modified or enlarged in accordance with doctor’s recommendations.

 

Possible methods of cellular material administration:

  • Intravenously
  • In endometrium
  • Other methods of local administration

 

Quantity of cell material for stem cell program in Gynecology (ovarian dysfunction): up to 30 mln of stem cells.

*Accommodation is not included but can be organized additionally.

*In case of using your own stem cell material, 2 visits are needed. Package price rises by 25%

The most common causes of infertility are Asherman’s syndrome, chronic endometritis, polyps, endometrial hypoplasia, uterine synechiae, and low endometrial thickness.

As per a successful pregnancy, not only high-quality embryos are needed, but also a healthy and mature woman’s endometrium. It guarantees the embryo’s implantation and the start of a pregnancy.

The most common causes of infertility are Asherman’s syndrome, chronic endometritis, polyps, endometrial hypoplasia, uterine synechiae, and low endometrial thickness.

The endometrium is a special model of physiological angiogenesis in adult women because it is a complex, constantly regenerating tissue.

We are using successful renewal therapy in case of thin and non-receptive endometrium.

  • 20+ patient`s exams included
  • 2 doctor`s consultations
  • Up to 30 mln of stem cells
  • Medical follow up for 1 year
  • 24/7 support
  • Translation
  • Transfer

Medical examination before stem cell therapy in Gynecology:

Included:

  • General blood test and leukocyte formula, 1 day
  • Vitamin D
  • D-dimer
  • Complex “Infectious monitoring of the patient” Complex “Infectious monitoring of the patient”
  • Rapid test for the diagnosis of multi-infection (HIV, hepatitis B HBSAg, hepatitis C, syphilis)
  • Coagulogram: prothrombin time (PP), prothrombin index (PTI), international normalized ratio (MNO, INR), percentage of prothrombin according to Quick, thrombin time (PM), activated partial thromboplastin (APTT), fibrinogen 1F
  • Complex “Lipidogram”: cholesterol, triglycerides, HDL, LDL, atherogenic factor, 1 day
  • General analysis of urine, 1 day
  • Urea, 1 day
  • Creatinine, 1 day
  • Bilirubin fractional (total, direct, indirect), 1 day
  • Glycated hemoglobin (HbA1c), 1 day
  • Alanine aminotransferase (ALT), 1 day
  • Aspartate aminotransferase (AST), 1 day
  • Alkaline phosphatase (LF), 1 day
  • Human chorionic gonadotropin (beta-HCG) total, 1 day
  • Oncomarker of ovarian cancer (CA-125), 2 days
  • Breast cancer tumor marker (CA-153), 2 days
  • Prostate-specific antigen total (Total PSA), 1 day
  • Initial consultation with a therapist

 

The list of examination can be modified or enlarged in accordance with doctor’s recommendations.

 

Possible methods of cellular material administration:

  • Intravenously
  • In endometrium
  • Other methods of local administration

 

Quantity of cell material for stem cell program in Gynecology: up to 60 mln of stem cells.

*Accommodation is not included but can be organized additionally.

*In case of using your own stem cell material, 2 visits are needed. Package price rises by 25%

Stem cell treatment procedure is practically painless and well-tolerated by patients, if necessary, performed anesthesia. Possible short-term side effects are redness at the injection site. These effects usually subside in 1 to 2 hours. The method of administration of cellular material is chosen by the doctor individually for each case.

Schedule:

Day 1 – arrival to the clinic and passing medical tests (in case the arrival is too late for it, tests will be made during the day2);

Day 2 – consultation with a specialized doctor, analysis of test results & stem cells injections;

Day 3 – free day departure.

Patient response to treatment is dependent on a large variety of biological factors, however is also subject to the behavior and lifestyle of the patient. We advise patients that stem cell therapy normally produces measurable results within 3-6-9 months following treatment. However, we have had many patients record improvements to their quality of life and a lessening of their symptoms within the first few weeks following treatment. Every patient is unique and will respond to treatment differently so it is impossible to guarantee any specific result for an individual, as every person’s body is different and will respond in different ways.

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